Hydroxypropyl Methylcellulose (HPMC) wani nau'in cellulose ne da aka saba amfani dashi tare da aikace-aikace iri-iri, kamar magani, abinci, kayan gini da kayan kwalliya. HPMC ba ion ba ne, Semi-synthetic, polymer inert tare da kyakkyawan solubility na ruwa, kauri, mannewa da abubuwan ƙirƙirar fim.
Tsarin da kaddarorin HPMC
HPMC shine cellulose da aka gyara wanda aka samar ta hanyar amsa cellulose tare da methyl chloride da propylene oxide. Tsarinsa na kwayoyin halitta ya ƙunshi duka methyl da hydroxypropyl, waɗanda ke ba HPMC keɓaɓɓen kaddarorin jiki da sinadarai, kamar kyakkyawan solubility, kariyar colloid da abubuwan ƙirƙirar fim. Ana iya raba HPMC zuwa ƙayyadaddun bayanai da yawa bisa ga madogara daban-daban, kuma kowane ƙayyadaddun yana da mabambantan solubility da amfani a cikin ruwa.
Solubility na HPMC a cikin ruwa
Tsarin rushewa
HPMC yana hulɗa da kwayoyin ruwa ta hanyar haɗin hydrogen don samar da mafita. Tsarinsa na rushewa ya haɗa da kwayoyin ruwa suna shiga a hankali tsakanin sarƙoƙin ƙwayoyin cuta na HPMC, suna lalata haɗin kai, ta yadda sarƙoƙin polymer ke yaɗuwa cikin ruwa don samar da mafita iri ɗaya. Solubility na HPMC yana da alaƙa ta kusa da nauyin kwayoyin sa, nau'in maye gurbinsa da digiri na maye gurbin (DS). Gabaɗaya, mafi girman matakin maye gurbin, mafi girman solubility na HPMC a cikin ruwa.
Tasirin zafin jiki akan solubility
Zazzabi yana ɗaya daga cikin mahimman abubuwan da ke shafar solubility na HPMC. Solubility na HPMC a cikin ruwa yana nuna halaye daban-daban yayin da yanayin zafi ya canza:
Kewayon zafin jiki na narkewa: HPMC yana da wahala a narke cikin ruwan sanyi (gaba ɗaya ƙasa da 40°C), amma yana iya narke da sauri lokacin mai zafi zuwa 60°C ko sama. Don ƙananan danko na HPMC, zafin ruwa na kusan 60°C shine mafi kyawun yanayin narkewa. Don HPMC mai tsananin danko, mafi kyawun kewayon narkar da zafin jiki na iya zama sama da 80°C.
Gelation a lokacin sanyaya: Lokacin da aka yi zafi da maganin HPMC zuwa wani zazzabi (yawanci 60-80 ° C) yayin rushewa sannan kuma a hankali sanyaya, za a samar da gel na thermal. Wannan gel ɗin thermal ya zama barga bayan sanyaya zuwa zafin jiki kuma ana iya sake tarwatsa shi cikin ruwan sanyi. Wannan al'amari yana da ma'ana mai girma ga shirye-shiryen mafita na HPMC don wasu takamaiman dalilai (kamar magungunan dorewar-saki).
Ƙarfafawar Rushewa: Gabaɗaya, yanayin zafi mai girma na iya haɓaka aikin rushewar HPMC. Koyaya, yawan zafin jiki kuma yana iya haifar da lalacewa ta polymer ko raguwa a cikin ɗankowar narkewa. Sabili da haka, a cikin ainihin aiki, yakamata a zaɓi yanayin zafin da ya dace kamar yadda ake buƙata don guje wa lalacewa mara amfani da canje-canje na dukiya.
Tasirin pH akan solubility
A matsayin ba-ionic polymer, solubility na HPMC a cikin ruwa ba a kai tsaye shafi pH darajar da mafita. Koyaya, matsanancin yanayin pH (kamar ƙaƙƙarfan mahallin acidic ko alkaline) na iya shafar halayen rushewar HPMC:
Yanayin acidic: A ƙarƙashin yanayi mai ƙarfi na acidic (pH <3), wasu haɗin sinadarai na HPMC (kamar ether bond) na iya lalata su ta matsakaicin acidic, ta haka yana shafar solubility da dispersibility. Koyaya, a cikin kewayon acid mai rauni gabaɗaya (pH 3-6), HPMC na iya narkar da shi da kyau. Sharuɗɗan alkaline: A ƙarƙashin ƙaƙƙarfan yanayin alkaline (pH> 11), HPMC na iya ƙasƙantar da shi, wanda yawanci saboda halayen hydrolysis na sarkar hydroxypropyl. A karkashin raunin alkaline yanayi (pH 7-9), da solubility na HPMC yawanci ba shi da muhimmanci.
Hanyar rushewar HPMC
Domin narkar da HPMC yadda ya kamata, yawanci ana amfani da waɗannan hanyoyin:
Hanyar watsa ruwan sanyi: A hankali ƙara HPMC foda a cikin ruwan sanyi yayin motsawa don tarwatsa shi daidai. Wannan hanya na iya hana HPMC daga kai tsaye agglomerating a cikin ruwa, da kuma bayani ya samar da colloidal kariya Layer. Sa'an nan kuma, a hankali zafi shi zuwa 60-80 ° C don narkar da shi sosai. Wannan hanya ta dace da rushe yawancin HPMC.
Hanyar watsa ruwan zafi: Ƙara HPMC zuwa ruwan zafi kuma motsa shi da sauri don narkar da shi da sauri a babban zafin jiki. Wannan hanya ta dace da HPMC mai tsananin danko, amma ya kamata a kula da sarrafa zafin jiki don guje wa lalacewa.
Hanyar shirye-shiryen Magani: Na farko, ana narkar da HPMC a cikin wani kaushi mai ƙarfi (kamar ethanol), sannan a hankali ƙara ruwa don canza shi zuwa maganin ruwa. Wannan hanyar ta dace da yanayin aikace-aikacen musamman tare da buƙatun solubility.
Ayyukan rushewa a aikace-aikace masu amfani
A aikace-aikace masu amfani, tsarin rushewar HPMC yana buƙatar ingantawa bisa ga takamaiman amfani. Alal misali, a cikin filin magani, yawanci ya zama dole don samar da wani tsari mai mahimmanci da kwanciyar hankali na colloidal, kuma ana buƙatar tsananin kula da zafin jiki da pH don tabbatar da danko da aikin nazarin halittu na maganin. A cikin kayan gini, solubility na HPMC yana rinjayar kaddarorin samar da fina-finai da ƙarfin matsawa, don haka mafi kyawun hanyar rushewa yana buƙatar zaɓi a hade tare da takamaiman yanayin muhalli.
Solubility na HPMC a cikin ruwa yana shafar abubuwa da yawa, musamman zafin jiki da pH. Gabaɗaya magana, HPMC yana narkar da sauri a yanayin zafi mai girma (60-80°C), amma yana iya ƙasƙanta ko ya zama ƙasa mai narkewa a ƙarƙashin matsanancin yanayin pH. Sabili da haka, a cikin aikace-aikacen aikace-aikacen, ya zama dole don zaɓar yanayin zafin da ya dace da yanayin narkewa da kewayon pH bisa ga takamaiman amfani da yanayin muhalli na HPMC don tabbatar da ingantaccen narkewa da aiki.
Lokacin aikawa: Juni-25-2024