Hydroxypropylmethylcellulose (HPMC) wani fili ne wanda ya zama babban ɗanyen abu a masana'antu da yawa saboda kaddarorinsa masu yawa. Ana amfani da ita azaman ƙari na abinci, mai kauri a cikin kayan kwalliya, har ma da kayan aikin likitanci a cikin magunguna da yawa. Samar da musamman na HPMC shine halayen thixotropic, wanda ke ba shi damar canza danko da kaddarorin kwarara a ƙarƙashin wasu yanayi. Bugu da kari, duka high-danko da kuma low-viscosity HPMC suna da wannan dukiya, nuna thixotropy ko da a kasa da gel zafin jiki.
Thixotropy yana faruwa a cikin HPMC lokacin da bayani ya zama mai laushi lokacin da aka yi amfani da matsa lamba ko motsa jiki, yana haifar da raguwa a cikin danko. Wannan hali kuma za a iya juya shi; lokacin da aka cire damuwa kuma an bar maganin ya huta, danko a hankali ya dawo zuwa matsayi mafi girma. Wannan ƙayyadaddun kadarorin yana sa HPMC ya zama muhimmin sashi a masana'antu da yawa saboda yana ba da izinin aikace-aikacen santsi da sauƙin sarrafawa.
A matsayin nonionic hydrocolloid, HPMC yana kumbura cikin ruwa don samar da gel. Matsayin kumburi da gelling ya dogara da nauyin kwayoyin halitta da kuma maida hankali na polymer, pH da zafin jiki na maganin. High danko HPMC yawanci yana da babban kwayoyin nauyi da kuma samar da wani babban danko gel, yayin da low danko HPMC yana da low kwayoyin nauyi da kuma samar da kasa danko gel. Koyaya, duk da waɗannan bambance-bambance a cikin aikin, nau'ikan HPMC guda biyu suna nuna thixotropy saboda canje-canjen tsarin da ke faruwa a matakin ƙwayoyin cuta.
Halin thixotropic na HPMC shine sakamakon daidaitawar sarƙoƙin polymer saboda damuwa mai ƙarfi. Lokacin da aka yi amfani da danniya mai ƙarfi ga HPMC, sarƙoƙi na polymer suna daidaitawa a cikin yanayin da ake amfani da su, wanda ya haifar da lalata tsarin cibiyar sadarwa mai girma uku wanda ya kasance a cikin rashin damuwa. Rushewar hanyar sadarwar yana haifar da raguwar dankon bayani. Lokacin da aka cire damuwa, sarƙoƙi na polymer suna sake tsarawa tare da ainihin yanayin su, sake gina hanyar sadarwa da dawo da danko.
Har ila yau, HPMC yana nuna thixotropy a ƙasa da zafin jiki na gelling. Zazzabi na gel shine zafin jiki wanda sarƙoƙin polymer ke ƙetare hanyar haɗin gwiwa don samar da hanyar sadarwa mai girma uku, ƙirƙirar gel. Ya dogara da ƙaddamarwa, nauyin kwayoyin halitta da pH na maganin polymer. Sakamakon gel yana da babban danko kuma baya canzawa da sauri a ƙarƙashin matsin lamba. Duk da haka, a ƙasa da zafin jiki na gelation, maganin HPMC ya kasance mai ruwa, amma har yanzu yana nuna halayen thixotropic saboda kasancewar wani ɓangaren tsarin cibiyar sadarwa. Cibiyar sadarwar da aka kafa ta waɗannan sassa tana rushewa a ƙarƙashin matsin lamba, yana haifar da raguwa a cikin danko. Wannan hali yana da amfani a yawancin aikace-aikace inda mafita ke buƙatar gudana cikin sauƙi lokacin da aka zuga.
HPMC sinadari ce mai jujjuyawa tare da kaddarorin da yawa, ɗayansu shine halayen thixotropic. Dukansu high-danko da ƙananan danko HPMCs suna da wannan dukiya, suna nuna thixotropy ko da ƙasa da zafin jiki na gel. Wannan halayyar ta sa HPMC ta zama wani abu mai mahimmanci a cikin masana'antu da yawa waɗanda ke buƙatar mafita waɗanda ke ɗaukar sauƙi don tabbatar da aikace-aikacen santsi. Duk da bambance-bambance a cikin kaddarorin da ke tsakanin babban danko da ƙarancin danko na HPMCs, halayen thixotropic na su yana faruwa saboda daidaitawa da rushewar tsarin cibiyar sadarwa da aka kafa. Saboda kaddarorin sa na musamman, masu bincike koyaushe suna bincika aikace-aikacen HPMC daban-daban, suna fatan ƙirƙirar sabbin samfura da samar da mafi kyawun mafita ga masu amfani a duniya.
Lokacin aikawa: Agusta-23-2023