HPMC (hydroxypropyl methylcellulose) mai kauri ne kuma mai ƙarfi wanda aka saba amfani dashi a cikin kayan gini, sutura, magunguna da abinci. HPMC 15 cps yana nufin cewa ɗankowar sa shine 15 centipoise, wanda shine ƙaramin ɗanƙoƙi.
1. Ƙara yawan maida hankali na HPMC
Hanya mafi kai tsaye da tasiri don ƙara danko na HPMC shine ƙara yawan maida hankali a cikin maganin. Lokacin da yawan juzu'i na HPMC ya karu, dankon maganin kuma zai karu. Tushen wannan hanyar ita ce HPMC tana ƙara ɗanɗanon maganin ta hanyar samar da tsarin cibiyar sadarwa mai girma uku. Yayin da adadin kwayoyin HPMC a cikin maganin ya karu, yawa da ƙarfin tsarin cibiyar sadarwa kuma za su karu, don haka ƙara danko na maganin. Duk da haka, akwai iyaka don ƙara maida hankali. Yawan maida hankali na HPMC zai haifar da raguwar ruwan maganin, kuma yana iya shafar aikinta a takamaiman aikace-aikace, kamar gini da aiki.
2. Sarrafa yawan zafin jiki na maganin
Zazzabi yana da babban tasiri akan solubility da danko na HPMC. A ƙananan yanayin zafi, danko na maganin HPMC ya fi girma; yayin da a yanayin zafi mafi girma, dankowar maganin HPMC zai ragu. Saboda haka, rage yawan zafin jiki na maganin daidai lokacin amfani zai iya ƙara danko na HPMC. Ya kamata a lura cewa solubility na HPMC a cikin maganin ya bambanta a yanayin zafi daban-daban. Yawancin lokaci yana da sauƙin tarwatsawa cikin ruwan sanyi, amma yana ɗaukar ɗan lokaci kaɗan don narke gaba ɗaya. Yana narkewa da sauri a cikin ruwan dumi, amma danko yana ƙasa.
3. Canja darajar pH na sauran ƙarfi
Dankowar HPMC kuma yana kula da ƙimar pH na maganin. Ƙarƙashin tsaka-tsaki ko kusa-tsakiyar yanayi, dankowar maganin HPMC shine mafi girma. Idan darajar pH na maganin ya bambanta daga tsaka tsaki, danko na iya raguwa. Sabili da haka, ana iya ƙara dankowar maganin HPMC ta hanyar daidaita ƙimar pH da kyau (alal misali, ta ƙara mai buffer ko mai sarrafa tushen acid). Duk da haka, a cikin ainihin aiki, daidaitawar ƙimar pH ya kamata a yi taka tsantsan, saboda manyan canje-canje na iya haifar da lalacewar HPMC ko lalata aikin.
4. Zabi mai dacewa da sauran ƙarfi
A solubility da danko na HPMC a daban-daban sauran ƙarfi tsarin ne daban-daban. Kodayake ana amfani da HPMC galibi a cikin mafita mai ruwa, ƙari na wasu abubuwan kaushi na halitta (kamar ethanol, isopropanol, da sauransu) ko gishiri daban-daban na iya canza tsarin sarkar kwayar halittar HPMC, ta haka yana shafar danko. Alal misali, ƙananan ƙwayar ƙwayar cuta na iya rage tsangwama na kwayoyin ruwa akan HPMC, don haka ƙara danko na maganin. A cikin ƙayyadaddun ayyuka, ya zama dole don zaɓar masu kaushi mai dacewa bisa ga ainihin aikace-aikacen.
5. Yi amfani da kayan kauri
A wasu lokuta, ana iya ƙara wasu kayan aikin kauri zuwa HPMC don cimma tasirin ƙara danko. Abubuwan da ake amfani da su na kauri sun haɗa da xanthan danko, guar danko, carbomer, da sauransu. Waɗannan abubuwan ƙari suna hulɗa tare da kwayoyin HPMC don samar da gel mai ƙarfi ko tsarin cibiyar sadarwa, yana ƙara ƙara danƙon mafita. Misali, xanthan danko shine polysaccharide na halitta tare da tasiri mai ƙarfi mai ƙarfi. Lokacin da aka yi amfani da su tare da HPMC, su biyun na iya haifar da sakamako na haɗin gwiwa kuma suna haɓaka danko na tsarin sosai.
6. Canja matakin maye gurbin HPMC
Dankowar HPMC shima yana da alaƙa da matakin maye gurbin ƙungiyar methoxy da hydroxypropoxy. Matsayin maye gurbin yana rinjayar solubility da danko na maganin. Ta zaɓin HPMC tare da digiri daban-daban na maye gurbin, za a iya daidaita danko na maganin. Idan ana buƙatar mafi girma danko HPMC, samfurin tare da mafi girma methoxy abun ciki za a iya zaba, saboda mafi girma da methoxy abun ciki, da karfi da hydrophobicity na HPMC, da danko bayan rushe ne in mun gwada da high.
7. Tsawaita lokacin rushewa
Lokacin da HPMC ke narkewa shima zai shafi dankon sa. Idan HPMC ba a narkar da gaba daya ba, dankowar maganin ba zai kai ga kyakkyawan yanayin ba. Saboda haka, yadda ya kamata mika lokacin narkar da HPMC a cikin ruwa don tabbatar da cewa HPMC ya cika ruwa sosai zai iya haɓaka dankowar maganinta yadda ya kamata. Musamman lokacin narkar da a ƙananan yanayin zafi, tsarin narkarwar HPMC na iya zama a hankali, kuma tsawaita lokacin yana da mahimmanci.
8. Canja yanayin juzu'i
Dankowar HPMC kuma yana da alaƙa da ƙarfin ƙarfi da aka yi masa yayin amfani. A ƙarƙashin babban yanayin shear, dankowar maganin HPMC zai ragu na ɗan lokaci, amma lokacin da juzu'in ya tsaya, danko zai dawo. Don matakan da ke buƙatar ƙara yawan danko, za a iya rage girman ƙarfin da aka yi wa maganin, ko kuma za'a iya sarrafa shi a ƙarƙashin ƙananan yanayi don kula da danko mafi girma.
9. Zaɓi nauyin kwayoyin daidai
Nauyin kwayoyin halitta na HPMC kai tsaye yana rinjayar danko. HPMC tare da mafi girman nauyin kwayoyin halitta yana samar da tsarin cibiyar sadarwa mafi girma a cikin maganin, yana haifar da danko mafi girma. Idan kana buƙatar ƙara danko na HPMC, zaka iya zaɓar samfuran HPMC tare da nauyin kwayoyin mafi girma. Ko da yake HPMC 15 cps samfuri ne mai ƙarancin danko, ana iya ƙara danko ta zaɓi babban nau'in nau'in nau'in nau'in samfurin iri ɗaya.
10. Yi la'akari da abubuwan muhalli
Abubuwan muhalli kamar zafi da matsa lamba na iya samun wani tasiri akan ɗankowar maganin HPMC. A cikin yanayin zafi mai yawa, HPMC na iya ɗaukar danshi daga iska, yana haifar da ɗankowar sa ya ragu. Don kauce wa wannan, ana iya sarrafa yanayin muhalli na samarwa ko wurin amfani da kyau don kiyaye yanayin bushewa da kuma matsa lamba mai dacewa don kula da danko na maganin HPMC.
Akwai hanyoyi da yawa don ƙara danko na HPMC 15 cps bayani, ciki har da ƙara maida hankali, sarrafa zafin jiki, daidaitawa pH, ta yin amfani da thickening aids, zabi dace mataki na musanya da kwayoyin nauyi, da dai sauransu A takamaiman hanyar da za a zaba ya dogara da ainihin aikace-aikace. labari da bukatun aiwatarwa. A cikin ainihin aiki, sau da yawa ya zama dole don la'akari da dalilai da yawa da yin gyare-gyare masu dacewa da ingantawa don tabbatar da mafi kyawun aikin maganin HPMC a cikin takamaiman aikace-aikace.
Lokacin aikawa: Oktoba-16-2024