Rukuni: shafi kayan; Kayan aikin membrane; Kayan kwalliya na sauri-sarrafawa don shirye-shiryen saki; Tsayayyen wakili; Dakatar da agaji, adanawa na kwamfutar hannu; Karfafa wakilin mawumi.
1. Gabatarwar Samfurin
Wannan samfurin shine ethher wanda ba ionic ba, a cikin gaggawa a matsayin farin foda, mara kyale a cikin ruwa da mafi yawan ruwan sanyi don share ko dan kadan mai sanyi. Maganin mai ruwa mai zurfi yana da aiki mai zurfi, babban gaskiya da kwanciyar hankali. HPMC yana da kayan gel ɗin zafi. Bayan dumama, samfurin samfurin mafita siffofin gel hazo, sannan ya rushe bayan sanyaya. A cikin zafin jiki na ƙayyadaddun bayanai daban-daban ya bambanta. Canjin canje-canje da danko tare da danko, ƙwararrun ƙwararraki da yawa, mafi girma ƙididdigar hpmc yana da wasu bambance-bambance na wasu bambance-bambance na HPMC suna da wasu bambance-bambance da darajar ba a shafa su ba.
A cikin wani yanayi ya hada zafin jiki, da yawa, ragi na gaskiya da zazzabi na zazzabi sun kasance 360, 1.326g / cm3 da 170 ℃, bi da bi ℃, bi da shi. Bayan tsanani, yana juya launin ruwan kasa a 190 ~ 200 ° C da ƙonewa a 225 ~ 230 ° C.
HPMC kusan insolable ne a cikin chloroform, ethanol (95%), da kuma narkar da a cakuda Ethhanol da methylne chloride, da cakuda ruwa da ethylene chloride, da kuma cakuda ruwa da ethylene chloride, da kuma cakuda ruwa da ethylene chloride, da kuma cakuda ruwa da ethylene. Wasu matakan HPMC suna narkewa a cikin gaurayawan acetone, methylene chloride, da 2-propannol, da kuma a wasu abubuwan da ke tattare da su.
Tebur 1: Alamar Fasaha
shiri
Ma'auni,
60 GD (2910).
65GD (2906)
75GD (2208)
Metoxy%
28.0-32.0
27.0-300
19.0-24.0
Hydroxyproxy%
7.0-12.0
4.0-7.5
4.0-12.0
Gel zazzabi ℃
56-64.
62.0-68.0
70-90.0
Dankowar danko.
3,5,6,15,50,4000
50400 0
100400 0150 00100 000
Bushe nauyi asarar%
5.0 ko kasa
Burning saura%
1.5 ko ƙasa da ƙasa
pH
4.0-8.0
Karfe mai nauyi
20 ko ƙasa da haka
arsenic
2.0 ko ƙasa da ƙasa
2. Abubuwan Samfura
2.1 Hydroxypyl methylcellilose an narkar da shi a cikin ruwan sanyi don samar da maganin cututtukan gani na visciidal. Muddin an ƙara ruwan sanyi da ɗan zuga, ana iya narkar da shi cikin mafita. Akasin haka, yana da ban mamaki a cikin ruwan zafi sama da 60 ℃ kuma na iya kumbura. A cikin shirye-shiryen hydroxypomropyl methicicelle bayani bayani, ya fi kyau ƙara wani yanki na hydroxyprulose, kuma a ƙarshe amfani da ruwan sanyi don ƙarin ruwan da ake buƙata.
2.2 Hydroxypoys Hydroxypyl methylcellulose ether ne wanda ba ionic ba, ba zai iya amsawa da silts na Ionic ba, don tabbatar da cewa HPMC baya amsawa tare da wasu albarkatun ƙarfe da compifics a cikin aiwatar da samarwa.
2.3 Hydroxypoys Hydroxypyl methylcellulise yana da ƙarfi anti-mend, kuma tare da karuwar masarauta a cikin tsarin kwayoyin, ana inganta maganganu. Magunguna ta amfani da HPMC azaman cheerifies suna da inganci mai inganci a cikin aiki mai inganci fiye da magunguna ta amfani da sauran compifial na gargajiya (sitaci, sugar, powark, sukari mai narkewa).
2.4 hydroxypyl methylcellulose ne metertically metert. A matsayina na compceutical compectical, ba a narkar da shi ba ko sha, don haka ba ya samar da zafi a cikin kwayoyi da abinci. Yana da aikace-aikace na musamman don ƙarancin ƙimar ƙimar, gishiri-free, magunguna marasa gishiri, marasa alfarma da abinci ga masu ciwon sukari.
2.5HPMC ya kasance mai tsayayye zuwa acid da acid, amma idan pH ya wuce 2 ~ 24 kuma ya shafa ta mafi yawan zafin jiki ko lokacin ajiya, zai rage digiri na girma.
2.6 hydroxypyl methylcellulous bayani bayani na iya samar da aiki na gaba, nuna matsakaici na matsakaici da kyawawan dabi'un tayar da hankali. Yana da ingantaccen emulsification a cikin tsarin biyu na kashi kuma ana iya amfani dashi azaman ingantaccen mai kariya da Colloid mai kariya.
2.7 hydroxypoys Hydroxypyl methylcelos bayani yana da kyau kwarai kayan fim, kuma wani abu ne mai kyau na allo da kwayoyi. A membrrane ya kirkira ta ba shi da launi kuma mai tauri. Idan an ƙara glycol,, za a ƙara yawan filayenta. Bayan jiyya na jiki, ana tarwatsa samfurin a cikin ruwan sanyi, kuma ana iya sarrafa ragin rushewa ta canza yanayin ph. Ana amfani dashi a cikin shirye-shiryen saki da shirye-shiryen da aka rufe.
3. Aikace-aikace samfurin
3.1. Amfani da shi azaman wakili da kuma rarraba wakili
Ana amfani da HPMC don inganta matsalar ƙwayoyin cuta da kuma matakan saki, ana iya narkar da kai tsaye a cikin mawuyacin bayani da kuma abubuwan da aka gano kawai, gabaɗaya ~ 5%.
HPMC ruwa mafi sauki da kuma wani taro na ethanol don yin wani m minder; Misali: 2% HPMC mai ruwa-ruwa na HPMC an yi amfani da shi da maganin 55% na cututtukan Amoxicillin ya karu daga kashi 38% zuwa 90% ba tare da HPMC ba.
HPMC za a iya yi da m m tare da taro daban-daban na sitaci slurry bayan rushewa; Rage Allunan mai rufi na erythromycin na erythromycins ya karu daga 38.26% zuwa 97.38% lokacin da 2% hpmc da 8% sitaci aka hade.
2.2. Yi kayan fim da kayan aiki
HPMC a matsayin abu mai narkewa mai ruwa mai narkewa yana da halaye masu zuwa: danko na matsakaici; Tsarin shafi mai sauki ne; Kyakkyawan fim samar da dukiya; Na iya kiyaye siffar yanki, rubutu; Za a iya danshi; Iya launi, dandano mai dandano. Ana amfani da wannan samfurin azaman kayan aikin ruwa mai narkewa don allunan da kwayoyin cuta tare da ƙarancin danko, kuma don fim ɗin fim ɗin da ba ruwa-ruwa da yawa, adadin amfanin amfanin ƙasa ne 2% -5%.
2.3, a matsayin wakili mai kauri da kuma manne ne kariya
HPMC da aka yi amfani da shi azaman Wakilin Thickening shine 0.45% ~ 1.0%, za'a iya amfani dashi azaman idonsa ya faɗi da kuma wucin gadi hawaye; Amfani da shi don ƙara kwanciyar hankali na manne mai tsabta, hana coarcence na ruwa, hazo, sashi na yau da kullun shine 0.5% ~ 1.5%.
2.4, a matsayin Blocker, jinkirin sakin abu, wakilin saki da wakilin pore
Ana amfani da samfurin danko mai zurfi na HPMC don shirya wakilan da aka saki da sarrafawa na gauraye kayan haɗi da kayan kwalliya. Babban samfurin mai ban sha'awa shine wakili mai kyau don ci gaba ko allon saki mai sarrafawa don fara ɗaukar nauyin irin waɗannan allunan don ɗaukar ingantaccen taro a jini.
2.5. Gel da kuma siyarwa matrix
Za'a iya shirya shirye-shiryen hydrogel da shirye-shiryen adasta na ciki ta hanyar amfani da halayyar hydrogel da HPMC a cikin ruwa.
2.6 kayan masarufi na halitta
Metronidazole aka gauraye da hpmc da polycoxylethylene 934 a cikin mahautsini don yin allunan saki saki wanda ke dauke da 250mg. A cikin gwajin distro na vitro ya nuna cewa shiri da sauri ya girka a ruwa, kuma sakin miyagun ƙwayoyi aka sarrafa ta yaduwa da carbon sarkar shakatawa. Aiwatar da dabbobi sun nuna cewa sabon tsarin sakin magani yana da kyawawan abubuwan mashin nazarin halittu zuwa bovine sublingu.
2.7, kamar yadda agajin dakatarwa
Babban danko na wannan samfurin shine kyakkyawan taimakon rigakafin shirye-shiryen dakatar ruwa, sashi na yau da kullun shine 0.5% ~ 1.5%.
4. Misalai na aikace-aikace
4.1 Fim mai bayani: HPMC 2kg, Tal 2kg, Castor Oil 1000ml, Propylene Glycol 1000ml, Propylene Glycol 13000ML, ruwa 47000ml, Pigment mai dacewa. Akwai hanyoyi guda biyu don yin shi.
4.1.1 Shiri na launuka masu narkewa mai rufi mai ruwa mai ruwa: ƙara adadin HPMC zuwa 95% na na dare, ya haɗa shi da sikirin guda biyu kuma a sami mafita a hankali don ƙirƙirar ingantacce. Mix kashi 80% na mafita (20% don yin ruwa) tare da adadin mai mai castor, twewe-80, da kuma propylene glycol.
4.1.2 Shirya ruwan insoluble pigment (kamar baƙin ƙarfe oxide) shafi na hpmc na ruwa na dare, da kuma ruwa da aka kara wa etpc daddare. 20% na wannan maganin ana fitar da shi don yin zane-zane, kuma sauran mafita na ƙarfe na ƙarfe, sannan kuma aka haɗa adadin adadin kayan aikin ciki kuma an haɗa adadin abubuwan da aka haɗe da shi. Tsarin mai shafi na shafi na shafi: zuba a kan takardar hatsi a cikin tukunyar sukari, bayan sarrafawa, ciyarwar iska a cikin 10 ~ 10min na iya spraying ciyar da iska don 55 ℃ 15min na iya spraying ciyar da zafi, mai bushe na iya fita daga tukunyar, a cikin bushewa don bushewa fiye da 8H.
4.2α-interferon ido na ido 50μg na ask.fl.0.01ml hydrochloric acid, gauraye da 90ml acid a cikin gilashin busasshiyar sanda, haifuwa da a cikin iska. Wannan samfurin an yi shi cikin kayan fim.
4.3 Cotrimoxolexazolexazole (0.4g ± 0.08G) SMZ (80 raga) 40kg (80 raga) 8KG, TMMC (80 raga) 8kg, 3kg, tmpeius (80 raga) 8kg, 3kg, TMP (80 raga) 8kg, kara da kara 5min. Tare da prefabricated 3% hpmc ruwa bayani, abu mai laushi, tare da grining 16 na allo gaba ɗaya, zagaye na raga duk da kalma (Smzco) Allunan (Smzco) Allunan (Smzco) Allunan. Wannan samfurin ana amfani da shi akasari a matsayin mai goge baki. Rushewar allunan shine 96% / 10min.
Allunan bututu na 4.4 (0.25G) bututun bututun 80 mish 25kg, sitaci (120 raga) 2.1kg, magnesium stealer da ya dace. Hanyar samarwa ita ce haɗi pipeoperic acid, sitaci, hpmc a ko'ina, da ethan m kalma, 16mm allo mai laushi. Tare da sitaci kamar yadda wakilin dunƙule, rushewar wannan kwamfutar hannu ba kasa da 80% / 2min, wanda ya fi girma samfuran a Japan.
4.5 Hawaye na wucin gadi HPMC-4000, HPMC-4500 ko hpmc-5000 0%, borax 0.47g, boraium chllobenylmonius bayani 0.10g, clornium chlorbenylmonius bayani 0.10g, clornium chlorbenylmonius bayani 0.10g, boraium chllobenylammonium bayani 0.10g, boraium chllobenylmonius bayani 0.10g, clorisium chllobenylmonius bayani 0.10g, boraium chllobenylmonius bayani 0.10g, da aka kara wa chllobenylmonius bayani 0.10g, boraium chllobenylmonius bayani 0.10) Hanyar samarwa ita ce HPMC a cikin ruwa na 15ml, a 80 ~ 90 ℃ 90 ℃ 100 na 100min C to 8.6 ° C. An yi amfani da wannan samfurin don rashi, abu ne mai kyau don hawaye, lokacin da ya kamata ya ƙara yawan wannan samfurin, 0.7% ~ 1.5% ya dace.
4.6 MethorthorthAlla sawa Allts Allts Rein gishiri 187.5MG, Lachose 40mg, 40.0 mghtg ~ 6.0.0.0. An shirya shi azaman Allon ta hanyar al'ada. Ana amfani da wannan samfurin azaman kayan saki.
4.7 Don avantomomylin ⅳ Allunan, 2149g Avantomomy dukiyar ⅳ mono Granules bushe 575g da 62.5g hydroxyprocelylocalpyloculose e-50 an kara wa allura 4.50 an kara wa allon gaba daya don samun ci gaba saki na Vanguard Mycin ⅳ Allunan. Ana amfani da wannan samfurin azaman jinkirin sakin abu.
4.8 Nifipine Dogused-Saki Granules 1 Part nifxypheryl 3 sassa greenchypropyl 3 sassa ethyl sel clvent A farashin saki da magunguna na granules bai shafa ta canjin ph ba kuma ya kasance mai hankali fiye da cewa akwai kasuwancin kasuwancin kasuwanci. Bayan sa'o'i 12 na baka na gargajiya, zaman lafiyar jikin mutum ya kasance 12mg / ml, kuma babu wani bambanci na mutum.
4.9 mydrochol hydrochloride dance capsule proprana m cakulan akida 6kg, microcrystalline sel 40kg, ƙara ruwa 50l don yin granules. HPMC1kg da EC 9kg sun gauraye a cikin hadewar da aka gauraye (Methanol = 1lmenol 2l 4l 2l / min spray a kan capsule tare da dutse mai cike da injin. Kowane kamfani yana dauke da 160mg na prrantolol hydrochlammillide propical barbashi.
4.10 Naprorol hicleton Allts an shirya shi ta hanyar hada danprorol hcl: HPMC: CMC-Na a rabo na 1: 0.25: 2.25. Resularancin ƙwayoyi ya kasance kusa da tsari na sifili tsakanin awanni 12.
Hakanan za'a iya sanya wasu kwayoyi da kayan jikin mutum, irin su da aka gauraye: hpmc: cmc-na bisa ga: 1: 1.25: 1.25; Alylprollol: HPMC bisa ga 1: 2.8: Ratio 2.92. Resularancin ƙwayoyi ya kasance kusa da tsari na sifili tsakanin awanni 12.
4.11 Allunan allunan gauraye na Uthynalosine sun shirya abubuwan da aka gauraye ta hanyar amfani da micro foda foda na silica gel: cmc-na: HPMC 1: 0.7: 4.4. Za'a iya fitar da miyagun ƙwayoyi don 12h duka a cikin vitro kuma a vivo, da kuma tsarin sakin layi yana da kyakkyawar hulɗa. Sakamakon gwajin kwanciyar hankali na haɓaka kwanciyar hankali kamar yadda ƙa'idodin FDA ke yi hasashen cewa rayuwar ajiya ta wannan samfurin ya kasance shekaru 2 har zuwa shekaru 2.
4.12 HPMC (50Mph s) (5 sassa), hpmc (4000 mpa) (sassa 3) da HPC1 an narkar da HPC1 na 6000 na silica, da kuma holtaminizer da aka bushe, kuma ya fesa tare da homogenizer. Wannan samfurin ya ƙunshi 80% na babban magani.
4.13 Therylline Hydrophilic Gel Skeleton Allts an lasafta bisa ga allon kwamfutar hannu, 18% -35 da aka shirya hpmc, wanda zai iya haifar da ingantaccen jini na jikin mutum don 12h bayan aikin baki.
Lokacin Post: Feb-0524