Hydroxypropyl methylcellulose (HPMC) wani fili ne da aka saba amfani da shi na polymer, ana amfani da shi sosai a gine-gine, magunguna, abinci da sauran masana'antu. A matsayin polymer mai narkewar ruwa, HPMC yana da kyakkyawar riƙewar ruwa, ƙirƙirar fim, kauri da kaddarorin emulsifying. Riƙewar ruwa yana ɗaya daga cikin mahimman kaddarorinsa a aikace-aikace da yawa, musamman a cikin kayan kamar siminti, turmi da sutura a cikin masana'antar gine-gine, wanda zai iya jinkirta fitar da ruwa da haɓaka aikin gini da ingancin samfurin ƙarshe. Koyaya, riƙewar ruwa na HPMC yana da alaƙa da alaƙa da canjin yanayin zafi a waje, kuma fahimtar wannan alaƙa yana da mahimmanci don aikace-aikacen sa a fannoni daban-daban.
1. Tsarin da riƙe ruwa na HPMC
Ana yin HPMC ta hanyar gyare-gyaren sinadarai na cellulose na halitta, galibi ta hanyar gabatar da ƙungiyoyin hydroxypropyl (-C3H7OH) da methyl (-CH3) a cikin sarkar cellulose, wanda ke ba shi kyakkyawar solubility da kaddarorin tsari. Ƙungiyoyin hydroxyl (-OH) a cikin kwayoyin HPMC suna iya samar da haɗin gwiwar hydrogen tare da kwayoyin ruwa. Saboda haka, HPMC na iya sha ruwa kuma ya haɗa da ruwa, yana nuna riƙewar ruwa.
Riƙewar ruwa yana nufin ikon wani abu don riƙe ruwa. Don HPMC, an fi bayyana shi a cikin ikonsa na kula da abun ciki na ruwa a cikin tsarin ta hanyar hydration, musamman ma a cikin yanayin zafi mai zafi ko yanayin zafi mai zafi, wanda zai iya hana saurin asarar ruwa da kuma kula da wettability na abu. Tun da hydration a cikin kwayoyin HPMC yana da alaƙa ta kud da kud da hulɗar tsarinsa na ƙwayoyin cuta, canjin zafin jiki zai shafi iyawar ruwa da riƙewar ruwa na HPMC kai tsaye.
2. Tasirin zafin jiki akan riƙe ruwa na HPMC
Dangantakar da ke tsakanin riƙe ruwa na HPMC da zafin jiki za a iya tattauna ta ta fuskoki biyu: ɗaya shine tasirin zafin jiki akan solubility na HPMC, ɗayan kuma shine tasirin zafin jiki akan tsarin kwayoyinsa da hydration.
2.1 Tasirin zafin jiki akan solubility na HPMC
Solubility na HPMC a cikin ruwa yana da alaƙa da zafin jiki. Gabaɗaya, solubility na HPMC yana ƙaruwa tare da ƙara yawan zafin jiki. Lokacin da zafin jiki ya tashi, ƙwayoyin ruwa suna samun ƙarin ƙarfin zafi, wanda ke haifar da raunin hulɗar da ke tsakanin kwayoyin ruwa, ta haka yana inganta rushewar. HPMC. Ga HPMC, haɓakar zafin jiki na iya sauƙaƙa samar da maganin colloidal, ta yadda zai haɓaka riƙe ruwa a cikin ruwa.
Duk da haka, ma high zafin jiki na iya ƙara danko na HPMC bayani, shafi ta rheological Properties da dispersibility. Ko da yake wannan tasiri yana da kyau don inganta solubility, maɗaukakiyar zafin jiki na iya canza kwanciyar hankali na tsarin kwayoyin halitta kuma ya haifar da raguwa a cikin ruwa.
2.2 Tasirin zafin jiki akan tsarin kwayoyin halitta na HPMC
A cikin tsarin kwayoyin halitta na HPMC, haɗin gwiwar hydrogen an samo su ne da kwayoyin ruwa ta hanyar ƙungiyoyin hydroxyl, kuma wannan haɗin hydrogen yana da mahimmanci ga riƙewar ruwa na HPMC. Yayin da zafin jiki ya karu, ƙarfin haɗin hydrogen na iya canzawa, yana haifar da raunin dauri tsakanin kwayoyin HPMC da kwayoyin ruwa, don haka ya shafi riƙewar ruwa. Musamman, haɓakar zafin jiki zai haifar da haɗin gwiwar hydrogen a cikin kwayoyin HPMC don rarrabuwa, ta yadda zai rage shayar da ruwa da ƙarfin riƙe ruwa.
Bugu da kari, yanayin zafin jiki na HPMC shima yana nunawa a cikin halayen lokaci na maganin sa. HPMC tare da nau'ikan ma'auni daban-daban da ƙungiyoyi masu maye gurbin daban-daban suna da mabanbantan yanayin zafi. Gabaɗaya magana, ƙananan nauyin kwayoyin HPMC ya fi kula da zafin jiki, yayin da babban nauyin kwayoyin halitta na HPMC yana nuna ƙarin aiki. Sabili da haka, a cikin aikace-aikacen aikace-aikacen, ya zama dole don zaɓar nau'in HPMC mai dacewa bisa ga ƙayyadaddun yanayin zafin jiki don tabbatar da riƙewar ruwa a yanayin zafin aiki.
2.3 Tasirin zafin jiki akan ƙawancen ruwa
A cikin yanayin zafi mai zafi, riƙewar ruwa na HPMC zai shafi saurin ƙawancen ruwa da ya haifar da karuwar zafin jiki. Lokacin da zafin jiki na waje ya yi yawa, ruwan da ke cikin tsarin HPMC yana iya yin ƙaura. Ko da yake HPMC na iya riƙe ruwa zuwa wani ɗan lokaci ta hanyar tsarinsa na ƙwayoyin cuta, yawan zafin jiki da yawa na iya sa tsarin ya rasa ruwa da sauri fiye da ƙarfin riƙe ruwa na HPMC. A wannan yanayin, an hana ɗaukar ruwa na HPMC, musamman a cikin yanayin zafi mai zafi da bushewa.
Don rage wannan matsala, wasu nazarin sun nuna cewa ƙara masu humectants masu dacewa ko daidaita wasu abubuwan da ke cikin dabara na iya inganta tasirin ruwa na HPMC a cikin yanayin zafi mai zafi. Misali, ta hanyar daidaita gyare-gyaren danko a cikin dabara ko zaɓin ƙarancin ƙarfi mai ƙarfi, ana iya inganta riƙewar ruwa na HPMC zuwa wani ɗan lokaci, rage tasirin haɓakar zafin jiki akan ƙashin ruwa.
3. Abubuwa masu tasiri
Sakamakon zafin jiki a kan riƙewar ruwa na HPMC ya dogara ba kawai a kan yanayin zafin jiki da kanta ba, har ma a kan nauyin kwayoyin halitta, digiri na maye gurbin, ƙaddamarwar bayani da sauran abubuwan HPMC. Misali:
Nauyin kwayoyin halitta:HPMC tare da mafi girman nauyin kwayoyin halitta yawanci yana da ƙarfin riƙe ruwa, saboda tsarin cibiyar sadarwa da aka kafa ta manyan sarƙoƙi masu nauyi a cikin maganin zai iya ɗaukar ruwa da kuma riƙe ruwa yadda ya kamata.
Matsayin maye gurbin: Matsayin methylation da hydroxypropylation na HPMC zai shafi hulɗar ta tare da kwayoyin ruwa, ta haka yana rinjayar riƙewar ruwa. Gabaɗaya magana, babban matakin maye gurbin zai iya haɓaka haɓakar ruwa na HPMC, ta haka inganta riƙe ruwa.
Matsakaicin Magani: Matsalolin HPMC shima yana shafar riƙewar ruwa. Maɗaukaki mafi girma na mafita na HPMC yawanci suna da ingantattun tasirin riƙewar ruwa, saboda babban taro na HPMC na iya riƙe ruwa ta hanyar hulɗar intermolecular masu ƙarfi.
Akwai hadaddun dangantaka tsakanin riƙe ruwa naHPMCda zafin jiki. Ƙara yawan zafin jiki yana inganta narkewar HPMC kuma yana iya haifar da ingantaccen riƙewar ruwa, amma yawan zafin jiki zai lalata tsarin kwayoyin halitta na HPMC, ya rage ikonsa na ɗaure da ruwa, don haka yana rinjayar tasirin ruwa. Don cimma mafi kyawun aikin riƙe ruwa a ƙarƙashin yanayin zafin jiki daban-daban, ya zama dole don zaɓar nau'in HPMC mai dacewa bisa ga ƙayyadaddun buƙatun aikace-aikacen kuma daidaita daidaitattun yanayin amfani. Bugu da kari, sauran abubuwan da ke cikin dabara da dabarun sarrafa zafin jiki suma na iya inganta kiyaye ruwa na HPMC a cikin yanayin zafi mai zafi zuwa wani matsayi.
Lokacin aikawa: Nov-11-2024