Hydroxypropyl Methylcellulose (HPMC) wani muhimmin abin da aka samu na ether cellulose ne wanda aka yi amfani da shi sosai a fagagen masana'antu da yawa saboda keɓaɓɓen kayan sa na zahiri da sinadarai. Kaddarorin danko suna ɗaya daga cikin mahimman kaddarorin HPMC, suna shafar aikin sa kai tsaye a aikace-aikace daban-daban.
1. Abubuwan asali na HPMC
HPMC ne nonionic cellulose ether samu ta maye gurbin wani ɓangare na hydroxyl kungiyoyin (-OH) a cikin cellulose kwayoyin tare da methoxy kungiyoyin (-OCH3) da hydroxypropyl kungiyoyin (-OCH2CH (OH) CH3). Yana da kyau solubility a cikin ruwa da kuma wasu kwayoyin kaushi, forming m colloidal mafita. An ƙayyade dankowar HPMC da nauyinsa na kwayoyin halitta, matakin maye gurbinsa (DS, Degree of Substitution) da kuma rarraba madadin.
2. Tabbatar da danko na HPMC
Ana auna dankowar mafita na HPMC ta amfani da na'ura mai jujjuyawa ko na'urar viscometer na capillary. Lokacin aunawa, ana buƙatar kulawa da hankali ga maida hankali, zafin jiki da ƙimar maganin, saboda waɗannan abubuwan zasu iya tasiri sosai ga ƙimar danko.
Maganganun hankali: Dankowar HPMC yana ƙaruwa tare da haɓakar maida hankali. Lokacin da maida hankali na maganin HPMC ya kasance ƙasa, hulɗar tsakanin kwayoyin halitta yana da rauni kuma danko yana ƙasa. Yayin da maida hankali ya karu, haɗuwa da hulɗar tsakanin kwayoyin halitta yana ƙaruwa, yana haifar da karuwa mai yawa a cikin danko.
Zazzabi: Dankin mafita na HPMC yana da matukar damuwa ga zafin jiki. Gabaɗaya, yayin da zafin jiki ya ƙaru, dankowar maganin HPMC zai ragu. Wannan ya faru ne saboda haɓakar zafin jiki wanda ke haifar da haɓakar motsin ƙwayoyin cuta da raunin hulɗar intermolecular. Ya kamata a lura cewa HPMC tare da digiri daban-daban na maye gurbin da nauyin kwayoyin suna da hankali daban-daban ga zafin jiki.
Ƙimar shear: Maganin HPMC suna nuna halayen pseudoplastic (shear thinning), watau danko ya fi girma a ƙananan ƙimar shear kuma yana raguwa a babban ƙimar shear. Wannan hali ya samo asali ne saboda rundunonin ƙarfi waɗanda ke daidaita sarƙoƙi na ƙwayoyin cuta tare da jagorar juzu'i, ta yadda za a rage haɗama da mu'amala tsakanin kwayoyin halitta.
3. Abubuwan da ke damun HPMC danko
Nauyin kwayoyin halitta: Nauyin kwayoyin halitta na HPMC yana ɗaya daga cikin mahimman abubuwan da ke ƙayyade danƙon sa. Gabaɗaya magana, mafi girman nauyin kwayoyin halitta, mafi girma da danko na maganin. Wannan saboda kwayoyin HPMC masu nauyin nauyin kwayoyin suna da yuwuwar samar da hanyoyin sadarwa masu kama da juna, ta haka suna kara juzu'i na ciki na maganin.
Digiri na canji da rarraba maye: Lamba da rarraba abubuwan maye gurbin methoxy da hydroxypropyl a cikin HPMC suma suna shafar ɗankowar sa. Gabaɗaya, mafi girman matakin maye gurbin methoxy (DS), ƙananan danko na HPMC, saboda gabatarwar abubuwan maye gurbin methoxy zai rage ƙarfin haɗin gwiwar hydrogen tsakanin kwayoyin halitta. Gabatar da abubuwan maye gurbin hydroxypropyl zai haɓaka hulɗar intermolecular, ta haka ƙara danko. Bugu da ƙari, daidaitattun rarraba abubuwan maye gurbin suna taimakawa wajen samar da tsarin ingantaccen tsari da kuma ƙara danko na bayani.
Ƙimar pH na maganin: Kodayake HPMC ba polymer ba ce kuma dankonta ba ta kula da canje-canje a cikin ƙimar pH na maganin, matsananciyar ƙimar pH (sosai acidic ko alkaline sosai) na iya haifar da lalata tsarin kwayoyin halitta. HPMC, don haka yana shafar danko.
4. Filin aikace-aikacen HPMC
Saboda kyawawan halayen danko, HPMC ana amfani dashi sosai a fannoni da yawa:
Kayan gini: A cikin kayan gini, ana amfani da HPMC azaman mai kauri da mai riƙe ruwa don haɓaka aikin gini da haɓaka juriya.
Masana'antar harhada magunguna: A cikin masana'antar harhada magunguna, ana amfani da HPMC azaman abin ɗaure don allunan, wakili mai ƙirƙirar fim don capsules da mai ɗaukar magunguna masu ɗorewa.
Masana'antar abinci: Ana amfani da HPMC azaman mai kauri da daidaitawa a cikin masana'antar abinci don samar da ice cream, jelly da kayayyakin kiwo.
Kayayyakin sinadarai na yau da kullun: A cikin samfuran sinadarai na yau da kullun, ana amfani da HPMC azaman mai kauri da ƙarfi don samar da shamfu, gel ɗin shawa, man goge baki, da sauransu.
Halayen danko na HPMC sune tushe don kyakkyawan aiki a aikace-aikace daban-daban. Ta hanyar sarrafa nauyin kwayoyin halitta, digiri na maye, da yanayin mafita na HPMC, ana iya daidaita dankon sa don saduwa da buƙatun aikace-aikace daban-daban. A nan gaba, zurfafa bincike a kan dangantakar dake tsakanin HPMC kwayoyin tsarin da danko zai taimaka wajen inganta HPMC kayayyakin da mafi kyau yi da kuma kara fadada ta aikace-aikace filayen.
Lokacin aikawa: Yuli-20-2024