Hydroxypropyl Methylcellulose (HPMC) wani nau'in polymer ne da aka yi amfani da shi a cikin masana'antu daban-daban ciki har da magunguna, gini, abinci, da kayan shafawa.An samo shi daga cellulose, polymer na halitta wanda aka samo a cikin tsire-tsire.HPMC ana yabawa sosai don ƙirƙirar fim ɗin sa, kauri, daidaitawa, da abubuwan riƙe ruwa.A cikin masana'antu na harhada magunguna, ana yawanci amfani dashi azaman magunguna a cikin sifofin gargajiya na baka, shirye-shiryen ophthalmic, tsarin bayarwa na bayarwa.
Ana iya rarraba HPMC bisa ga sigogi da yawa da suka haɗa da nauyin kwayoyin sa, matakin maye gurbinsa, da girman barbashi.Anan akwai bayyani na nau'ikan HPMC daban-daban dangane da waɗannan sigogi:
Dangane da Nauyin Kwayoyin:
High Molecular Weight HPMC: Wannan nau'in HPMC yana da mafi girman nauyin kwayoyin halitta, yana haifar da ingantaccen danko da kaddarorin samar da fim.Yawancin lokaci ana fifita shi a aikace-aikace inda ake buƙatar mafi girman danko, kamar a cikin tsarin sarrafawa-saki.
Low Molecular Weight HPMC: Akasin haka, ƙananan nauyin kwayoyin HPMC yana da ƙananan danko kuma ana amfani dashi a aikace-aikace inda ake so ƙananan danko da saurin rushewa.
Dangane da Digiri na Sauya (DS):
Babban Sauyawa HPMC (HPMC-HS): HPMC tare da babban matsayi na canji yawanci yana nuna mafi kyawu a cikin ruwa kuma ana iya amfani dashi a cikin abubuwan da ke buƙatar rushewar cikin sauri.
Sauya Matsakaici HPMC (HPMC-MS): Wannan nau'in HPMC yana ba da daidaito tsakanin solubility da danko.An fi amfani da shi a cikin nau'ikan magunguna daban-daban.
Ƙananan Sauya HPMC (HPMC-LS): HPMC tare da ƙaramin digiri na canji yana ba da ƙimar rushewar hankali da ƙarin danko.Yawancin lokaci ana amfani da shi a cikin sifofin saƙo mai dorewa.
Dangane da Girman Barbashi:
Fine Barbashi Girman HPMC: HPMC tare da karami barbashi size yayi mafi kyau kwarara Properties kuma yawanci fĩfĩta a cikin m sashi siffofin kamar Allunan da capsules.
Bayyan girman girman HPMC: barbashi mai kula sun dace da aikace-aikace inda aka saki ko sakin-sakin-saki ana so.Ana amfani da su da yawa a cikin allunan matrix da pellets.
Darajoji na Musamman:
HPMC mai ciki: Wannan nau'in HPMC an kera shi ne musamman don tsayayya da ruwa na ciki, yana ba shi damar wucewa ta cikin ciki kuma ya saki maganin a cikin hanji.Ana yawan amfani da shi don magunguna masu kula da pH na ciki ko don bayarwa da aka yi niyya.
Dorewawar Sakin HPMC: An ƙirƙira waɗannan ƙirarru don sakin sinadarin mai aiki a hankali na tsawon lokaci mai tsawo, yana haifar da tsawaita aikin miyagun ƙwayoyi da rage yawan adadin kuzari.Ana amfani da su sau da yawa a cikin yanayi na yau da kullun inda kiyaye matakan ƙwayoyi akai-akai a cikin jini yana da mahimmanci.
Haɗin Maki:
HPMC-Acetate Succinate (HPMC-AS): Wannan nau'in HPMC ya haɗu da kaddarorin HPMC da ƙungiyoyin acetyl, yana sa ya dace da suturar ciki da tsarin isar da magunguna na pH.
HPMC-Phthalate (HPMC-P): HPMC-P shine polymer mai dogara da pH wanda aka saba amfani dashi a cikin suturar ciki don kare miyagun ƙwayoyi daga yanayin acidic a cikin ciki.
Abubuwan Haɗaɗɗiya na Musamman:
Masu sana'anta na iya ƙirƙirar gauraya na musamman na HPMC tare da wasu polymers ko abubuwan haɓaka don cimma takamaiman buƙatun ƙira kamar ingantattun bayanan bayanan magunguna, ingantacciyar kwanciyar hankali, ko mafi kyawun abubuwan rufe fuska.
Daban-daban kaddarorin na HPMC suna ba da damar amfani da shi a cikin nau'ikan nau'ikan magunguna daban-daban, kowannensu an keɓe shi don saduwa da takamaiman buƙatu kamar solubility, danko, sakin motsi, da kwanciyar hankali.Fahimtar nau'ikan HPMC daban-daban da halayensu yana da mahimmanci ga masu ƙira don tsara ingantaccen tsarin isar da magunguna.
Lokacin aikawa: Maris 19-2024