Hydroxypropyl methylcellulose, wanda aka fi sani da HPMC, kayan aikin magunguna ne da ake amfani da su sosai da ƙari na abinci.Saboda kyakkyawan narkewa, iyawar ɗauri da kaddarorin yin fim, an yi amfani da shi sosai a cikin masana'antar harhada magunguna.Hakanan ana amfani da HPMC a masana'antar abinci azaman mai kauri, emulsifier da stabilizer.Tsaftar HPMC yana da mahimmancin mahimmanci a cikin masana'antar harhada magunguna da masana'antar abinci saboda yana shafar inganci da amincin samfurin.Wannan labarin zai tattauna ƙaddarar tsabtar HPMC da hanyoyinsa.
Menene HPMCs?
Hydroxypropylmethylcellulose (HPMC) shine ether cellulose wanda aka samo daga methylcellulose.Nauyinsa na kwayoyin halitta Daltons 10,000 zuwa 1,000,000, kuma fari ne ko fari-fari, mara wari da dandano.HPMC yana da sauƙin narkewa a cikin ruwa, kuma yana narkewa a cikin wasu kaushi na halitta kamar ethanol, butanol, da chloroform.Yana da wasu kaddarori na musamman kamar riƙe ruwa, kauri da iya ɗaurewa, waɗanda suka sa ya dace da masana'antar harhada magunguna da abinci.
Ƙaddamar da tsabtar HPMC
Tsaftar HPMC ya dogara da abubuwa da yawa kamar matakin maye gurbin (DS), abun cikin danshi da abun cikin ash.DS yana wakiltar adadin ƙungiyoyin hydroxyl waɗanda ƙungiyoyin hydroxypropyl suka maye gurbinsu a cikin ƙwayoyin cellulose.Matsayi mai girma na maye yana ƙara solubility na HPMC kuma yana haɓaka ikon ƙirƙirar fim.Sabanin haka, ƙananan digiri na maye gurbin zai haifar da raguwar solubility da rashin kyawun kayan aikin fim.
Hanyar Tsaftace HPMC
Akwai hanyoyi da yawa don tantance tsaftar HPMC, gami da titration-base titration, bincike na asali, babban aikin ruwa chromatography (HPLC), da infrared spectroscopy (IR).Anan ga cikakkun bayanai ga kowace hanya:
acid-base titration
Hanyar ta dogara ne akan yanayin rashin daidaituwa tsakanin acidic da ƙungiyoyi na asali a cikin HPMC.Na farko, ana narkar da HPMC a cikin wani ƙarfi kuma an ƙara sanannen ƙarar acid ko tushe na sananniya.An yi titration har sai pH ya kai tsaka tsaki.Daga adadin acid ko tushe da aka cinye, ana iya ƙididdige matakin maye gurbin.
Binciken abubuwa
Binciken abubuwa yana auna adadin kowane nau'in da ke cikin samfurin, gami da carbon, hydrogen, da oxygen.Ana iya ƙididdige matakin maye gurbin daga adadin kowane nau'in da ke cikin samfurin HPMC.
Liquid Chromatography (HPLC) Babban Ayyuka
HPLC wata dabara ce ta nazari da ake amfani da ita sosai wacce ke raba sassan cakuduwar dangane da mu'amalarsu da matakan tsaye da na hannu.A cikin HPMC, ana iya ƙididdige matakin maye gurbin ta hanyar auna ma'aunin hydroxypropyl zuwa ƙungiyoyin methyl a cikin samfurin.
Infrared Spectroscopy (IR)
Infrared spectroscopy dabara ce ta nazari wacce ke auna sha ko watsawar hasken infrared ta hanyar samfur.HPMC yana da kololuwar shaye-shaye daban-daban don hydroxyl, methyl da hydroxypropyl, waɗanda za a iya amfani da su don tantance matakin maye gurbin.
Tsaftar HPMC yana da mahimmanci a cikin masana'antar harhada magunguna da abinci, kuma ƙudurinsa yana da mahimmanci don tabbatar da aminci da ingancin samfurin ƙarshe.Akwai hanyoyi da yawa don tantance tsabtar HPMC, gami da titration-base titration, bincike na farko, HPLC, da IR.Kowace hanya tana da nata amfani da rashin amfani kuma za'a iya zaɓa bisa ga takamaiman bukatun aikace-aikacen.Don kiyaye tsabtar HPMC, dole ne a adana shi a bushe, wuri mai sanyi nesa da hasken rana da sauran gurɓatattun abubuwa.
Lokacin aikawa: Agusta-25-2023