Hydroxypoylylmethypripylmethlellulose (HPMC), kamar yadda aka saba amfani da polymer na lantarki da aka saba amfani da shi a cikin masana'antar harhada magunguna, ana amfani da shi a cikin mayafin tebur, saki mai sarrafawa da sauran tsarin bayarwa na magani. Ofaya daga cikin mahimman kaddarorin HPMC shine iyawarsa don riƙe ruwa, wanda ke shafar aikin ta azaman magunguna na magunguna. A cikin wannan labarin, zamu bincika abubuwan mahimman abubuwan da suka shafi riƙewar ruwa na HPMC, ciki har da nauyin kwayoyin, na nau'in.
nauyi na kwayoyin
Weightar nauyin hpmc yana taka muhimmiyar rawa wajen tantance ƙarfin riƙewar ta ruwa. Gabaɗaya, nauyi kwayoyin halitta hpmc ya fi hydrophilic fiye da ƙarancin ƙwayoyin cuta na HPMC kuma zai iya ɗaukar ƙarin ruwa. Wannan saboda mafi girman nauyi kwayoyin hpmcs suna da sarƙoƙi mai tsawo wanda zai iya kasancewa da yawa mai zurfi sosai, yana ƙara yawan ruwan da za a iya tunawa. Koyaya, ya kamata a lura cewa yawan ƙwayoyin kwayar cutar hpmc zai haifar da matsaloli kamar danko da kuma sarrafa matsaloli.
zaɓi
Wani batun da wanda ya shafi damar riƙewar riƙewar ruwa na HPMC shine nau'in maye gurbin. HPMC gabaɗaya yana zuwa cikin siffofin biyu: hydroxypropyl-maye da metoxy-maye. Nau'in nau'in hydroxypyl-musayar yana da damar ɗaukar ruwa fiye da nau'in metoxy-siga. Wannan saboda ƙungiyar hydroxypyl ke gabatarwa a cikin kwayar cutar HPMC ta kasance mai amfani da ruwa kuma yana ƙara dangantakar HPMC don ruwa. Sabanin haka, nau'in sauƙin metoxy ne ƙasa da ƙarancin hydrophilic sabili da haka yana da ƙananan ƙarfin riƙe ruwa. Saboda haka, zaɓin HPMAC ya zaɓi zaɓi a hankali dangane da abubuwan da ake so na samfurin ƙarshe.
mai da hankali kan
A maida hankali ne na HPMC shima yana shafar karfin riƙe da ruwa. A low maida hankali, HPMC ba ta samar da tsarin Gel-kamar, don haka damar da kake iya karancin sa. Kamar yadda maida hankali ne na HPMC ya karu, kwayoyin polymer sun fara aiki, suna samar da tsarin gel-kamar tsari. Wannan cibiyar sadarwar gel ta sha kuma riƙe ruwa, kuma karfin riƙewar ruwa na HPMC yana ƙaruwa da taro. Koyaya, ya kamata a lura cewa daɗaɗaɗɗen hpmc zai haifar da matsalolin tsara tsarin kamar danko da kuma sarrafa matsaloli. Sabili da haka, an inganta tattarawa a HPMC da aka yi amfani da shi don cimma ƙarfin riƙe ribar da ake so yayin guje wa matsalolin da aka ambata a sama.
Ph darajar
Ana amfani da darajar muhalli na muhalli inda ake amfani da HPMC zai iya shafar ƙarfin riƙe riƙewar ruwa. Tsarin HPMC ya ƙunshi ƙungiyoyi na anionic (-coo-) da ƙungiyoyin etdrophilic gungun (-Oh). The ionization na -coo- Groungiyoyi ne ph dogara, kuma digiri na ioni ya ƙaruwa da pH. Saboda haka, HPMC tana da mafi girman ƙarfin riƙe ruwa a babban pH. A low ph, da -coo- Drungiyoyin sun nuna kuma hydrophility yana rage, sakamakon shi cikin karamin ikon ruwa riƙe ruwa. Sabili da haka, ya kamata a ficewar muhalli don cimma nasarar ɗaukar hpmc da ake so na HPMC.
A ƙarshe
A ƙarshe, ƙarfin riƙewar riƙe HPMC na HPMC shine babban mahimmancin mahimmancin aikinta azaman compecceutical curifivent. Abubuwan da suka shafi mahimman abubuwan da suka shafi yiwuwar hana rasuwar ruwa ta HPMC sun hada da nauyin kwayar halitta, nau'in juzu'i, maida hankali da darajar pH. Ta hanyar daidaita waɗannan abubuwan, ana iya inganta ƙarfin riƙe HPMC ta HPMC don cimma nasarar cimma burin da ake so na ƙarshen samfurin. Masu binciken magunguna da masana'antun ya kamata su kula sosai da waɗannan dalilai don tabbatar da mafi inganci da kuma aikin magani na HPMC.
Lokaci: Aug-05-2023