Hydroxypropylmethylcellulose (HPMC), kamar yadda aka saba amfani da hydrophilic polymer a cikin Pharmaceutical masana'antu, ana amfani da ko'ina a kwamfutar hannu coatings, sarrafawa saki formulations da sauran miyagun ƙwayoyi bayarwa tsarin.Ɗaya daga cikin mahimman kaddarorin na HPMC shine ikonsa na riƙe ruwa, wanda ke shafar aikin sa a matsayin kayan haɓakar magunguna.A cikin wannan labarin, zamu bincika mahimman abubuwan da suka shafi riƙewar ruwa na HPMC, gami da nauyin kwayoyin halitta, nau'in maye gurbin, maida hankali, da pH.
nauyin kwayoyin halitta
Nauyin kwayoyin halitta na HPMC yana taka muhimmiyar rawa wajen tantance ƙarfin riƙe ruwa.Gabaɗaya, babban nauyin kwayoyin HPMC ya fi hydrophilic fiye da ƙananan nauyin kwayoyin halitta na HPMC kuma yana iya sha ruwa mai yawa.Wannan saboda mafi girman nauyin kwayoyin HPMCs suna da sarƙoƙi masu tsayi waɗanda zasu iya haɗawa da samar da hanyar sadarwa mai fa'ida, ƙara yawan ruwan da za'a iya sha.Duk da haka, ya kamata a lura da cewa yawan nauyin kwayoyin HPMC zai haifar da matsaloli kamar danko da matsalolin sarrafawa.
madadin
Wani abu da ke shafar ƙarfin riƙe ruwa na HPMC shine nau'in maye gurbin.HPMC gabaɗaya yana zuwa ta hanyoyi biyu: maye gurbin hydroxypropyl da maye gurbin methoxy.Nau'in maye gurbin hydroxypropyl yana da mafi girman ƙarfin sha ruwa fiye da nau'in maye gurbin methoxy.Wannan shi ne saboda ƙungiyar hydroxypropyl da ke cikin kwayoyin HPMC hydrophilic ne kuma yana ƙara alaƙar HPMC don ruwa.Sabanin haka, nau'in maye gurbin methoxy ba shi da ƙarancin hydrophilic don haka yana da ƙananan ƙarfin riƙe ruwa.Don haka, ya kamata a zaɓi madadin nau'ikan HPMC a hankali bisa abubuwan da ake so na samfurin ƙarshe.
maida hankali akan
Haɗin kai na HPMC kuma yana shafar ƙarfin riƙewar ruwa.A ƙananan ƙididdiga, HPMC ba ya samar da tsarin gel-kamar, don haka ƙarfin riƙewar ruwa yana da ƙasa.Yayin da maida hankali na HPMC ya karu, kwayoyin polymer sun fara haɗuwa, suna samar da tsari mai kama da gel.Wannan hanyar sadarwar gel tana sha kuma tana riƙe da ruwa, kuma ƙarfin riƙewar ruwa na HPMC yana ƙaruwa tare da maida hankali.Duk da haka, ya kamata a lura cewa yawan maida hankali na HPMC zai haifar da matsalolin ƙira kamar danko da matsalolin sarrafawa.Don haka, ya kamata a inganta yawan adadin HPMC da aka yi amfani da shi don cimma ƙarfin riƙe ruwa da ake so yayin guje wa matsalolin da aka ambata a sama.
PH darajar
Ƙimar pH na muhallin da ake amfani da HPMC zai kuma shafi ƙarfin riƙe ruwa.Tsarin HPMC ya ƙunshi ƙungiyoyin anionic (-COO-) da ƙungiyoyin ethylcellulose na hydrophilic (-OH).Ƙungiyoyin ionization na -COO sun dogara da pH, kuma digiri na ionization yana ƙaruwa tare da pH.Sabili da haka, HPMC yana da ƙarfin riƙe ruwa mafi girma a babban pH.A ƙananan pH, ƙungiyar -COO- tana haɓakawa kuma hydrophilicity yana raguwa, yana haifar da ƙananan ƙarfin riƙe ruwa.Don haka, ya kamata a inganta pH na muhalli don cimma ƙarfin riƙe ruwa da ake so na HPMC.
a karshe
A ƙarshe, ƙarfin riƙewar ruwa na HPMC shine maɓalli mai mahimmanci wanda ke shafar aikin sa azaman kayan haɓakar magunguna.Mahimman abubuwan da ke shafar ƙarfin riƙewar ruwa na HPMC sun haɗa da nauyin kwayoyin halitta, nau'in maye gurbin, maida hankali da ƙimar pH.Ta hanyar daidaita waɗannan abubuwan a hankali, ana iya haɓaka ƙarfin riƙe ruwa na HPMC don cimma abubuwan da ake so na ƙarshen samfurin.Masu binciken harhada magunguna da masana'antun ya kamata su kula sosai ga waɗannan abubuwan don tabbatar da inganci mafi girma da aiki na ƙirar magunguna na tushen HPMC.
Lokacin aikawa: Agusta-05-2023